For worship or praise lead, one possible goal is dominant distortion without a separately audible clean dry sound, clear notes, controlled fizz, and preserved sustain. Separate drive, EQ, ambience, and noise problems. Start with ambience off; check direct monitoring; choose the correct capture; set input drive, tone/cab, and output balance, then add ambience.
Smooth does not have to mean clean. Bright does not require maximum Presence. A muffled sound is not always short of treble: excess low-mid energy can hide clarity. Reducing a crowded band can sometimes help more than repeatedly boosting the highs. Stacking several overdrives can help, but does not automatically make a tone thicker or better.
For worship bass, preserve the fundamental and control dynamics, choose low-mid body and articulation, then compare in the band's context. A Bass knob position that suits one model may not suit another. New strings, pickups, onboard EQ, headphones, and amp/cab all affect the result.
For Acoustic Simulator, use a clean DI, choose the appropriate pickup mode, and evaluate middle/neck and bridge separately. Middle or neck can be useful starting points. Bridge can still work with appropriate correction; the result depends on the pickup and playing. Parlor and Parlor Pick are modes within one block, rather than two new effect engines. Acoustic low cut and feedback notches have different purposes from brightening EQ.